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📋Overview
Chronic Myeloid Leukemia is a type of blood cancer that begins in the blood-forming cells of the bone marrow and leads to an oversupply of myeloid cells. This condition is fundamentally linked to a genetic abnormality called the Philadelphia chromosome, which is formed when parts of chromosomes 9 and 22 swap places to create the BCR-ABL1 fusion gene.
The resulting BCR-ABL1 gene produces an abnormal tyrosine kinase protein that allows white blood cells to grow uncontrollably and accumulate in the blood. This malignancy may progress through distinct clinical stages, categorized as the chronic, accelerated, and blast phases, as leukemic cells displace healthy blood components.
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