Finnish Type Amyloidosis

📋Overview

Finnish Type Amyloidosis, now more commonly referred to as hereditary gelsolin amyloidosis, is a genetic disorder involving the mutation of the gelsolin protein. This mutation causes the protein to misfold and aggregate into amyloid fibrils, which can gradually deposit in various tissues and organs.

This condition is typically inherited in an autosomal dominant pattern and is recognized for its progressive nature. Clinical observation of this systemic disorder involves the identification of mutated gelsolin protein fragments that accumulate as amyloid in extracellular spaces.