Human Cyclic Neutropenia

📋Overview

This condition is a form of congenital neutropenia that typically follows a predictable cycle, often occurring every 21 days. During these intervals, neutrophil counts may drop significantly, which can increase an individual's susceptibility to infections during the low phases of the cycle.

Most cases of this disorder are associated with mutations in the ELANE gene, which provides instructions for making a protein essential for the development and function of neutrophils. These genetic changes disrupt the normal production of white blood cells, leading to the characteristic cyclic pattern observed in affected individuals.