Hutchinson-Gilford Progeria Syndrome

📋Overview

Hutchinson-Gilford Progeria Syndrome is caused by a mutation in the LMNA gene, which results in the production of an abnormal protein called progerin. This protein causes cellular instability, leading to the accelerated aging process that typically becomes apparent within the first year of life.

The disorder generally occurs as a spontaneous genetic mutation rather than being inherited from parents. Affected children often appear healthy at birth, but they begin to show physical signs of the condition as the cellular damage from progerin accumulation progresses.