Langerhans Cell Histiocytosis

📋Overview

Langerhans Cell Histiocytosis is characterized by the proliferation of Langerhans cells, which are a type of dendritic cell typically involved in the body's immune response. This condition is classified as a clonal neoplastic disease that also exhibits inflammatory characteristics, potentially impacting the bones, skin, lungs, and other organ systems.

Historically referred to by terms such as Histiocytosis X, this disorder encompasses several clinical presentations previously known as eosinophilic granuloma, Hand-Schüller-Christian disease, and Letterer-Siwe disease. Modern clinical classification now groups these manifestations under a single diagnostic entity based on the underlying cellular pathology.