Lissencephaly

📋Overview

Lissencephaly is a rare malformation of the cerebral cortex that occurs when nerve cells fail to migrate to their proper positions during fetal development. This disruption in neuronal migration results in a brain surface that appears smooth, lacking the typical complex patterns of gyri and sulci.

Clinical classification of this condition often involves identifying specific structural patterns such as agyria, which is the complete absence of brain folds, or pachygyria, characterized by unusually broad and few folds. These cortical malformations are typically identified through neuroimaging and represent a spectrum of developmental brain disorders.