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📋Overview
Multiple System Atrophy (MSA) is a rare, progressive neurodegenerative disorder characterized by a combination of autonomic dysfunction, parkinsonism, and cerebellar ataxia. It is considered a synucleinopathy related to abnormal accumulation of alpha-synuclein protein in glial cells. MSA is the modern preferred term encompassing what was previously described under various legacy terms such as Shy-Drager syndrome, striatonigral degeneration, and olivopontocerebellar atrophy. These older terms are now recognized as clinical subtypes within MSA.
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