📋Overview
Rapp-Hodgkin syndrome is a legacy eponym historically used to describe a form of ectodermal dysplasia characterized by abnormalities in skin, hair, teeth, and nails, often overlapping clinically and genetically with Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) syndrome. Modern terminology classifies it within the spectrum of ectodermal dysplasias associated with mutations in the TP63 gene. These disorders affect the development of ectodermal structures and may include cleft lip and/or palate, skin erosions, and other features.
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