Systemic Mastocytosis

📋Overview

This condition involves the proliferation of mast cells within the bone marrow, liver, spleen, and gastrointestinal tract. Unlike cutaneous forms of the disease, this condition affects multiple organ systems and is classified as a mast cell neoplasm.

The accumulation of these cells can lead to the release of excessive chemical mediators, which may cause various systemic symptoms. Clinical identification often relies on finding these abnormal cells in extracutaneous sites such as the bone marrow.