Question 1

What is Aubagio?

Accepted Answer

Aubagio is a prescription medication classified as an immunomodulatory agent and a pyrimidine synthesis inhibitor. It functions by limiting the activity of specific immune cells that are associated with inflammation and damage to the central nervous system.

By regulating these immune responses, the medication helps to manage the underlying disease process and reduce the frequency of clinical relapses. It is designed to influence the body's immune system to protect nerve fibers from further damage.

Question 2

What is Aubagio used for?

Accepted Answer

Aubagio is used to treat multiple sclerosis .

Question 3

How does Aubagio work?

Accepted Answer

Aubagio belongs to a class of drugs known as immunomodulatory agents. While the exact way it works to treat multiple sclerosis (MS) is not fully understood, it is believed to work by limiting the overactivity of the immune system.

In people with MS, certain white blood cells called lymphocytes attack the protective covering of nerves in the brain and spinal cord. Aubagio works by blocking a specific enzyme that these cells need to multiply quickly. By reducing the number of these activated immune cells, the medication helps:

Decrease inflammation: By lowering the number of activated immune cells, there is less inflammation in the central nervous system.

Lower relapse rates: Reducing the immune attack helps decrease the frequency of MS flare-ups.

Slow disability progression: By protecting nerves from damage, the medication can help slow the worsening of physical symptoms.

Because it targets the production of these cells, Aubagio helps prevent them from reaching the brain and spinal cord where they would otherwise cause damage to the nerves.

Question 4

What are the active ingredients in Aubagio?

Accepted Answer

The active ingredient in Aubagio is teriflunomide .

Question 5

What are the side effects of Aubagio?

Accepted Answer

Common side effects of Aubagio may include:

diarrhea

hair thinning

nausea

and others

Always consult with a healthcare professional about potential side effects.

Question 6

What drug class is Aubagio?

Accepted Answer

Aubagio belongs to the immunomodulator drug class.

Question 7

What is the dosage of Aubagio and how do I take it?

Accepted Answer

How to Take

Aubagio is a tablet taken by mouth, typically once per day. You may take it with or without food. It is recommended to take your dose at the same time every day to help you remember and to keep the medication levels steady in your system.

Missed Doses

If you miss a dose, take it as soon as you realize it. If it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular routine. Never take two doses at once to compensate for a missed one.

Usage Tips

Follow the instructions provided by your healthcare professional carefully.

Your doctor may require regular blood tests to monitor your liver health and blood pressure while you are on this medication.

Do not discontinue this medication without first discussing it with your doctor.

Question 8

Is Aubagio safe during pregnancy and breastfeeding?

Accepted Answer

Pregnancy Risks

Aubagio carries a high risk of causing severe birth defects or fetal death. It is contraindicated for use in pregnant women and those of childbearing potential who are not using reliable contraception. A pregnancy test is typically required before starting the medication to confirm the patient is not pregnant.

Long-term Presence in the Body

After stopping Aubagio, the drug can remain in the blood for up to two years. If a patient wishes to become pregnant or if an unplanned pregnancy occurs, healthcare providers may perform an accelerated elimination procedure. This involves taking specific medications, such as cholestyramine or activated charcoal, to help the body clear the drug more quickly.

Men taking Aubagio should also be aware that the drug can be passed through semen. Men who plan to father a child should talk to their doctor about the potential risks and the elimination procedure.

Breastfeeding

It is currently unknown if Aubagio is excreted in human breast milk. Because of the risk of serious adverse reactions in nursing infants, breastfeeding is not recommended while taking this medication. Patients should consult with their healthcare provider to weigh the benefits of treatment against the risks of breastfeeding.

Question 9

What forms and strengths does Aubagio come in?

Accepted Answer

Aubagio is available in the following form:

Film-coated tablet: This medication is an oral tablet intended to be swallowed whole.

Question 10

What is the FDA approval status of Aubagio?

Accepted Answer

FDA Approval and Indications

Aubagio (teriflunomide) is approved by the U.S. Food and Drug Administration (FDA) for the treatment of relapsing forms of multiple sclerosis (MS) in adults. The approved indications include:

Clinically isolated syndrome

Relapsing-remitting disease

Active secondary progressive disease

Boxed Warnings

The FDA requires a boxed warning for Aubagio due to two significant safety concerns:

Severe Liver Injury: There is a risk of severe liver damage, which can be fatal. Healthcare providers are required to conduct blood tests to evaluate liver function before starting the medication and continue monitoring periodically during treatment.

Teratogenicity (Birth Defects): Aubagio may cause serious birth defects or fetal death if taken during pregnancy. It is strictly contraindicated for use in pregnant women or women of childbearing potential who are not using effective contraception.

Safety Monitoring and Communications

The FDA monitors the safety profile of Aubagio through the FDA Adverse Event Reporting System (FAERS). Regulatory authorities have identified potential signals of serious risks, such as drug-induced liver injury, which are evaluated to ensure the medication's labeling remains accurate. Additionally, a pregnancy exposure registry exists to monitor the outcomes of individuals who may have been exposed to the drug during pregnancy.

Question 11

What should I know about Aubagio and cost?

Accepted Answer

Generic Availability

Generic versions of Aubagio, known as teriflunomide, are available. Generic medications typically cost significantly less than brand-name drugs while providing the same active ingredient and therapeutic effect.

Insurance and Prior Authorization

Most health insurance plans provide coverage for Aubagio or its generic equivalent, but the specific out-of-pocket cost depends on the plan's formulary. Many insurance companies require prior authorization, which means a healthcare provider must submit documentation to the insurer to justify the medical necessity of the drug before coverage is approved.

Specialty Pharmacy Requirements

Aubagio is often classified as a specialty medication. Because of this, it is frequently dispensed through specialty pharmacies rather than standard retail pharmacies. Specialty pharmacies may offer additional support services but can have different billing and delivery procedures.

Financial Assistance Programs

The manufacturer of Aubagio may offer patient assistance programs or copay cards to help reduce costs for eligible individuals. Additionally, some non-profit organizations provide financial support or grants for patients with multiple sclerosis who are unable to afford their medication.

Aubagio

Medication Quick Facts

📋Overview

What It's Used For

How It Works

Side Effects

Warnings & Precautions

Dosage & How to Take

Pregnancy & Breastfeeding

Forms & Strengths

FDA / Regulatory Status

Price Information

FAQ

Additional Resources

Support & Help Resources

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