Question 1

What is Edoxaban?

Accepted Answer

Edoxaban is a type of medication known as an anticoagulant. It belongs to a class of drugs called factor Xa inhibitors, which work by blocking a specific natural substance in the body that is involved in the blood clotting process.

By interfering with this process, the medication helps to reduce the formation of blood clots. This action is intended to lower the risk of serious medical complications associated with unwanted clotting in the body.

Question 2

What is Edoxaban used for?

Accepted Answer

Edoxaban is used to treat:

nonvalvular atrial fibrillation

deep vein thrombosis

pulmonary embolism

Question 3

How does Edoxaban work?

Accepted Answer

Mechanism of Action

Edoxaban belongs to a class of medications called factor Xa inhibitors. It works by directly blocking the activity of factor Xa, which is a key enzyme involved in the blood clotting process. Under normal conditions, factor Xa helps the body produce thrombin, a substance that triggers the formation of blood clots.

By inhibiting factor Xa, edoxaban reduces the amount of thrombin produced in the body. This makes the blood less likely to form clots and prevents existing clots from growing larger. Because it targets a specific step in the clotting sequence, it is often referred to as a direct oral anticoagulant (DOAC).

How It Affects the Body

When edoxaban is taken, it enters the bloodstream and begins to interfere with the coagulation cascade. This process is beneficial for individuals at risk of certain medical conditions, such as:

Stroke prevention: In people with an irregular heartbeat (atrial fibrillation), it helps prevent clots from forming in the heart and traveling to the brain.

Treating venous thromboembolism: It helps manage clots that form in the deep veins of the legs or travel to the lungs.

Unlike some older blood thinners, edoxaban works directly on the clotting factor without requiring additional proteins to be effective. Its effects generally begin shortly after the medication is absorbed into the system.

Question 4

What are the brand names for Edoxaban?

Accepted Answer

Edoxaban is sold under the brand names Savaysa and Lixiana .

Question 5

What are the active ingredients in Edoxaban?

Accepted Answer

The active ingredient in Edoxaban is edoxaban .

Question 6

What are the side effects of Edoxaban?

Accepted Answer

Common side effects of Edoxaban may include:

Bleeding

Anemia

Always consult with a healthcare professional about potential side effects.

Question 7

What drug class is Edoxaban?

Accepted Answer

Edoxaban belongs to the Factor Xa inhibitor drug class.

Question 8

What is the dosage of Edoxaban and how do I take it?

Accepted Answer

How to Take Edoxaban

Edoxaban is a tablet taken by mouth, usually once a day. You can take it with or without food. It is best to take your dose at the same time every day to help you remember and to keep the medicine working steadily in your body.

Administration Tips

You should generally swallow the tablet whole. If you have trouble swallowing pills, talk to your doctor or pharmacist. They may advise you to crush the tablet and mix it with a spoonful of applesauce or a small amount of water for immediate use. If mixed with water, the mixture can also be administered through certain types of feeding tubes by a healthcare professional.

Missed Dose

If you forget to take a dose, take it as soon as you remember on that same day. If you do not remember until the next day, skip the missed dose and take your next scheduled dose at the usual time. Never take two doses at once to make up for a missed one.

Important Usage Notes

Do not stop taking this medicine unless your doctor tells you to. Stopping edoxaban early can increase the risk of serious blood clots or a stroke. Make sure to refill your prescription early so you do not miss any doses.

Question 9

Is Edoxaban safe during pregnancy and breastfeeding?

Accepted Answer

Pregnancy

There is limited information regarding the safety of edoxaban use during pregnancy. While animal studies have not demonstrated a direct risk of birth defects, there are no adequate studies in humans to confirm its safety. Using blood thinners during pregnancy can increase the risk of bleeding for both the mother and the fetus.

Individuals who are pregnant or planning to become pregnant should consult with a healthcare professional to evaluate the risks and benefits. People of childbearing potential may be advised to use effective contraception while taking this medication.

Breastfeeding

It is not known if edoxaban passes into human breast milk. Because of the potential for serious side effects in a nursing infant, breastfeeding is generally not recommended during treatment. A decision should be made in consultation with a healthcare provider to either stop breastfeeding or stop taking the medication, based on the clinical necessity of the treatment for the mother.

Question 10

What forms and strengths does Edoxaban come in?

Accepted Answer

Edoxaban is available in the following form:

Oral Tablet: This medication is provided as a film-coated tablet for oral administration.

Question 11

What is the FDA approval status of Edoxaban?

Accepted Answer

The U.S. Food and Drug Administration (FDA) approved edoxaban for the following indications:

To reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF).

To treat deep vein thrombosis (DVT) and pulmonary embolism (PE) following 5 to 10 days of initial treatment with an injectable anticoagulant.

Edoxaban carries several boxed warnings, which are the most serious warnings required by the FDA to alert consumers and healthcare providers to significant safety risks:

Reduced Efficacy in NVAF with High Kidney Function: Edoxaban should not be used in patients with nonvalvular atrial fibrillation who have a creatinine clearance (CrCl) greater than 95 mL/min. Clinical trials indicated that these patients have an increased risk of ischemic stroke compared to those taking warfarin.

Risk of Stroke After Premature Discontinuation: Stopping edoxaban earlier than directed increases the risk of blood clots and stroke. If the medication must be stopped for reasons other than major bleeding, another anticoagulant should typically be started.

Spinal/Epidural Hematoma: Patients taking edoxaban who undergo spinal puncture or receive neuraxial anesthesia (such as an epidural) are at risk of developing a blood clot around the spine. These hematomas can cause long-term or permanent paralysis.

Edoxaban is also approved for use in other regions, including the United Kingdom and the European Union, where it is marketed under the brand name Lixiana for the prevention of stroke in atrial fibrillation and the treatment and prevention of DVT and PE.

Question 12

What should I know about Edoxaban and cost?

Accepted Answer

Factors Affecting Price

Several variables determine the final cost of edoxaban:

Insurance Plan: Most insurance providers cover edoxaban, but the specific tier and copay amount will vary by plan.

Pharmacy Location: Retail prices can differ between pharmacies; comparing prices at different locations or using mail-order options may reduce costs.

Supply Amount: Purchasing a 90-day supply instead of a 30-day supply may sometimes offer a lower cost per dose.

Generic Availability

Edoxaban is sold under the brand name Savaysa. Generic versions are generally more affordable than brand-name drugs. However, the availability of generic edoxaban depends on regional patent laws and regulatory approvals. You should consult your pharmacist to see if a generic alternative is available and covered by your insurance.

Assistance and Savings

Many manufacturers provide financial assistance for brand-name medications. This may include savings cards for those with commercial insurance or patient assistance programs for individuals who meet specific income requirements or lack insurance coverage.

Edoxaban

📋Overview

What It's Used For

How It Works

Brand Names

Side Effects

Warnings & Precautions

Dosage & How to Take

Pregnancy & Breastfeeding

Forms & Strengths

FDA / Regulatory Status

Price Information

FAQ

Additional Resources

Support & Help Resources

📚References

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Edoxaban Price Comparison & Savings Options

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