Q: How does Kerendia work?

Mechanism of Action Kerendia belongs to a class of medications known as non-steroidal mineralocorticoid receptor antagonists (MRAs). It works by targeting and blocking the mineralocorticoid receptor (MR) throughout the body. In people with chronic kidney disease and type 2 diabetes, these receptors can become overactive. When the MR is overstimulated, it can lead to several harmful effects, including: Inflammation: Increased swelling and irritation in the tissues. Fibrosis: The development of permanent scarring in the kidneys and heart. By blocking these receptors, Kerendia helps to prevent the damage caused by overactivation. This process helps slow the decline of kidney function and reduces the risk of serious cardiovascular events, such as heart failure, heart attacks, and the need for hospitalization.

Q: What are the active ingredients in Kerendia?

The active ingredient in Kerendia is finerenone .

Q: What are the side effects of Kerendia?

Common side effects of Kerendia may include: Hyperkalemia Hypotension Always consult with a healthcare professional about potential side effects.

Q: What drug class is Kerendia?

Kerendia belongs to the mineralocorticoid receptor antagonist drug class.

Q: What is the dosage of Kerendia and how do I take it?

How to Take Kerendia Kerendia is taken by mouth, usually once every day. You may take it with or without food. For the best results, try to take the medication at the same time each day. If you have trouble swallowing the tablet whole, you can crush it and mix it with a small amount of water or soft food, such as applesauce. This mixture should be consumed immediately. Missed Dose If you miss a dose of Kerendia, take it as soon as you remember on the same day. If you do not realize you missed the dose until the next day, skip the missed dose entirely and take your next dose at the regularly scheduled time. Never take two doses at once to make up for a missed one. Special Instructions Avoid consuming grapefruit or grapefruit juice while using this medication, as it can interfere with how the drug is processed in your body. Your healthcare provider will require regular blood tests to monitor your potassium levels and kidney function before you start treatment and periodically while you are taking this medicine.

Q: Is Kerendia safe during pregnancy and breastfeeding?

Pregnancy There is limited information regarding the use of Kerendia in pregnant women. Based on data from animal studies, this medication may cause harm to a developing fetus. Because of these potential risks, healthcare providers typically advise against using Kerendia during pregnancy. If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits of this treatment with your doctor. Your healthcare provider may also discuss the use of effective contraception while you are taking this medication. Breastfeeding It is not known if Kerendia passes into human breast milk. However, animal studies have shown that the drug is present in milk, which could pose a risk of serious side effects to a nursing child. To avoid potential risks, it is generally recommended that you do not breastfeed while taking Kerendia and for at least one day after your last dose. Consult your healthcare provider to discuss the best way to feed your baby during treatment.

Q: What is the FDA approval status of Kerendia?

FDA Approval Status The U.S. Food and Drug Administration (FDA) approved Kerendia on July 9, 2021. It was the first non-steroidal mineralocorticoid receptor antagonist (MRA) approved specifically for patients with chronic kidney disease (CKD) associated with type 2 diabetes. Approved Indications Kerendia is indicated to reduce the risk of several serious health outcomes in adults with CKD and type 2 diabetes, including: Sustained decline in estimated glomerular filtration rate (eGFR), which is a measure of kidney function. End-stage kidney disease. Cardiovascular death. Non-fatal heart attack (myocardial infarction). Hospitalization for heart failure. Safety and Monitoring There are currently no boxed warnings or Risk Evaluation and Mitigation Strategies (REMS) required for Kerendia. However, the FDA-approved labeling includes warnings regarding hyperkalemia (high potassium levels). Healthcare providers are required to monitor serum potassium levels and kidney function before starting treatment and periodically during use, as the medication can cause potassium levels to rise significantly.

Question 1

What is Kerendia?

Accepted Answer

Kerendia is a non-steroidal mineralocorticoid receptor antagonist (MRA). This medication works by blocking the activity of certain natural substances in the body that can cause damage to the heart and kidneys.

By binding to specific receptors, it helps to limit inflammation and the buildup of scar tissue. This action is intended to help preserve organ function and reduce the risk of long-term cardiovascular and renal complications.

Question 2

What is Kerendia used for?

Accepted Answer

Kerendia is used to treat chronic kidney disease associated with type 2 diabetes.

Question 3

How does Kerendia work?

Accepted Answer

Mechanism of Action

Kerendia belongs to a class of medications known as non-steroidal mineralocorticoid receptor antagonists (MRAs). It works by targeting and blocking the mineralocorticoid receptor (MR) throughout the body.

In people with chronic kidney disease and type 2 diabetes, these receptors can become overactive. When the MR is overstimulated, it can lead to several harmful effects, including:

Inflammation: Increased swelling and irritation in the tissues.
Fibrosis: The development of permanent scarring in the kidneys and heart.

By blocking these receptors, Kerendia helps to prevent the damage caused by overactivation. This process helps slow the decline of kidney function and reduces the risk of serious cardiovascular events, such as heart failure, heart attacks, and the need for hospitalization.

Question 4

What are the active ingredients in Kerendia?

Accepted Answer

The active ingredient in Kerendia is finerenone.

Question 5

What are the side effects of Kerendia?

Accepted Answer

Common side effects of Kerendia may include:

Hyperkalemia
Hypotension

Always consult with a healthcare professional about potential side effects.

Question 6

What drug class is Kerendia?

Accepted Answer

Kerendia belongs to the mineralocorticoid receptor antagonist drug class.

Question 7

What is the dosage of Kerendia and how do I take it?

Accepted Answer

How to Take Kerendia

Kerendia is taken by mouth, usually once every day. You may take it with or without food. For the best results, try to take the medication at the same time each day.

If you have trouble swallowing the tablet whole, you can crush it and mix it with a small amount of water or soft food, such as applesauce. This mixture should be consumed immediately.

Missed Dose

If you miss a dose of Kerendia, take it as soon as you remember on the same day. If you do not realize you missed the dose until the next day, skip the missed dose entirely and take your next dose at the regularly scheduled time. Never take two doses at once to make up for a missed one.

Special Instructions

Avoid consuming grapefruit or grapefruit juice while using this medication, as it can interfere with how the drug is processed in your body.
Your healthcare provider will require regular blood tests to monitor your potassium levels and kidney function before you start treatment and periodically while you are taking this medicine.

Question 8

Is Kerendia safe during pregnancy and breastfeeding?

Accepted Answer

Pregnancy

There is limited information regarding the use of Kerendia in pregnant women. Based on data from animal studies, this medication may cause harm to a developing fetus. Because of these potential risks, healthcare providers typically advise against using Kerendia during pregnancy.

If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits of this treatment with your doctor. Your healthcare provider may also discuss the use of effective contraception while you are taking this medication.

Breastfeeding

It is not known if Kerendia passes into human breast milk. However, animal studies have shown that the drug is present in milk, which could pose a risk of serious side effects to a nursing child.

To avoid potential risks, it is generally recommended that you do not breastfeed while taking Kerendia and for at least one day after your last dose. Consult your healthcare provider to discuss the best way to feed your baby during treatment.

Question 9

What forms and strengths does Kerendia come in?

Accepted Answer

Kerendia is supplied as a tablet for oral use. It is available in the following form:

Oral tablet

These tablets are film-coated and are intended to be swallowed as directed by a healthcare provider.

Question 10

What is the FDA approval status of Kerendia?

Accepted Answer

FDA Approval Status

The U.S. Food and Drug Administration (FDA) approved Kerendia on July 9, 2021. It was the first non-steroidal mineralocorticoid receptor antagonist (MRA) approved specifically for patients with chronic kidney disease (CKD) associated with type 2 diabetes.

Approved Indications

Kerendia is indicated to reduce the risk of several serious health outcomes in adults with CKD and type 2 diabetes, including:

Sustained decline in estimated glomerular filtration rate (eGFR), which is a measure of kidney function.
End-stage kidney disease.
Cardiovascular death.
Non-fatal heart attack (myocardial infarction).
Hospitalization for heart failure.

Safety and Monitoring

There are currently no boxed warnings or Risk Evaluation and Mitigation Strategies (REMS) required for Kerendia. However, the FDA-approved labeling includes warnings regarding hyperkalemia (high potassium levels). Healthcare providers are required to monitor serum potassium levels and kidney function before starting treatment and periodically during use, as the medication can cause potassium levels to rise significantly.

Question 11

What should I know about Kerendia and cost?

Accepted Answer

Estimated Retail Price

Without insurance, the list price for Kerendia is approximately $668 for a 30-day supply of either the 10 mg or 20 mg tablets. However, the actual price paid at the pharmacy can vary significantly depending on location and the specific pharmacy used.

Insurance Coverage

Most commercial insurance plans and Medicare Part D provide coverage for Kerendia. The out-of-pocket cost will depend on your plan's formulary, which determines your specific copay or coinsurance amount. Some plans may require prior authorization before they will cover the medication.

Financial Assistance and Savings

There are several options that may help reduce the cost of Kerendia for eligible patients:

Manufacturer Copay Cards: Patients with commercial insurance may be eligible for savings cards provided by the manufacturer to lower monthly out-of-pocket expenses.
Patient Assistance Programs: For individuals who are uninsured or underinsured, there may be programs available through the manufacturer or non-profit organizations that provide the medication at a reduced cost or for free based on financial need.
Pharmacy Discounts: Some pharmacies offer their own discount programs or work with third-party savings platforms that may provide a lower price than the standard retail rate.

It is recommended to contact your insurance provider or pharmacist to obtain the most accurate pricing information for your specific situation.

Kerendia

📋Overview

How It Works

Uses

Active Ingredients

Common Side Effects

Warnings & Precautions

Dosage

Pregnancy & Breastfeeding

Frequently Asked Questions

📚References

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