Question 1

What is Retevmo?

Accepted Answer

Retevmo is a kinase inhibitor that contains the active ingredient selpercatinib. It works by targeting and blocking the activity of RET proteins, which are enzymes that play a role in cell growth and division.

In some cancers, genetic changes cause these proteins to become overactive, leading to the uncontrolled multiplication of cells. By inhibiting these specific proteins, the medication helps to slow or stop the progression of the disease.

Question 2

What is Retevmo used for?

Accepted Answer

Retevmo is used to treat RET fusion-positive non-small cell lung cancer and RET-mutant medullary thyroid cancer .

Question 3

How does Retevmo work?

Accepted Answer

Targeting RET Proteins

Retevmo belongs to a class of drugs known as kinase inhibitors. It is specifically designed to target and block the activity of a protein called RET (Rearranged during Transfection).

In certain types of cancer, the RET gene undergoes changes, such as mutations or fusions. These genetic alterations cause the RET protein to become overactive. When this protein is constantly active, it sends continuous signals to cells, telling them to grow, multiply, and spread uncontrollably, leading to the formation of tumors.

How Retevmo Works

Retevmo works by binding to the abnormal RET protein and blocking its signaling pathway. By inhibiting this protein, the medication can:

Interrupt growth signals: It stops the messages that tell cancer cells to divide.

Slow tumor progression: By cutting off these signals, the drug helps shrink tumors or prevent them from getting larger.

Target specific cells: Because it focuses on the RET protein, it is considered a targeted therapy, though it may still affect some healthy cells in the body.

Before starting this treatment, healthcare providers typically use a laboratory test to confirm the presence of a RET gene fusion or mutation, ensuring the cancer is likely to respond to this specific mechanism.

Question 4

What are the active ingredients in Retevmo?

Accepted Answer

The active ingredient in Retevmo is selpercatinib .

Question 5

What are the side effects of Retevmo?

Accepted Answer

Common side effects of Retevmo may include:

dry mouth

diarrhea

fatigue

and others

Always consult with a healthcare professional about potential side effects.

Question 6

What drug class is Retevmo?

Accepted Answer

Retevmo belongs to the RET kinase inhibitor drug class.

Question 7

What is the dosage of Retevmo and how do I take it?

Accepted Answer

How to Take Retevmo

Retevmo is taken by mouth, usually twice a day at approximately the same times each day. You should swallow the capsules or tablets whole and avoid crushing or chewing them.

This medication can be taken with or without food. However, if you take certain stomach acid medications, such as proton pump inhibitors, H2 blockers, or antacids, your doctor may advise you to take Retevmo with a meal or at a specific time to ensure the drug is absorbed correctly.

Missed Doses

If you miss a dose of Retevmo, take it as soon as you remember. If your next dose is due soon, skip the missed dose and take the next one at your regular time. Do not take two doses at once to make up for a missed dose.

If you vomit after taking a dose, do not take an extra dose to replace it. Simply take your next dose at the scheduled time.

Question 8

Is Retevmo safe during pregnancy and breastfeeding?

Accepted Answer

Pregnancy

Retevmo can cause fetal harm when administered to a pregnant woman. Based on its mechanism of action and findings from animal studies, this medication may lead to birth defects or pregnancy loss. Healthcare providers typically require a pregnancy test before starting treatment for individuals who are able to become pregnant.

It is generally advised to use effective birth control during treatment and for at least one week after the final dose. This recommendation often applies to both females and males who have partners of reproductive potential.

Breastfeeding

It is not known whether Retevmo passes into breast milk or how it might affect a nursing child. Because of the potential for serious adverse reactions in an infant, breastfeeding is not recommended during treatment and for at least one week after the last dose.

Fertility

Retevmo may impair fertility in both males and females, which could affect the ability to have children. Individuals should discuss the potential impact on fertility with their healthcare provider before starting this medication.

Question 9

What forms and strengths does Retevmo come in?

Accepted Answer

Retevmo is supplied as a capsule for oral administration. The capsules are produced in different versions, which are distinguished by their color and the markings printed on the capsule shell.

Oral capsule

Question 10

What is the FDA approval status of Retevmo?

Accepted Answer

FDA Approval Status

Retevmo (selpercatinib) was first granted accelerated approval by the FDA in May 2020. It has since received full approval for several indications involving lung and thyroid cancers, while the approval for certain solid tumors remains under the accelerated approval pathway based on clinical trial response rates.

Approved Indications

Non-Small Cell Lung Cancer (NSCLC): Approved for adults with metastatic RET fusion-positive NSCLC.

Medullary Thyroid Cancer (MTC): Approved for adults and pediatric patients aged 12 and older with advanced or metastatic RET-mutant MTC who require systemic therapy.

Thyroid Cancer: Approved for adults and pediatric patients aged 12 and older with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are refractory to radioactive iodine.

Solid Tumors: Approved for adults with locally advanced or metastatic RET fusion-positive solid tumors that have progressed following prior systemic treatment or who have no satisfactory alternative treatment options.

Regulatory Requirements

The use of Retevmo requires confirmation of a RET gene alteration through an FDA-approved companion diagnostic test. There are no Boxed Warnings or Risk Evaluation and Mitigation Strategies (REMS) currently associated with this drug.

Question 11

What should I know about Retevmo and cost?

Accepted Answer

Factors Affecting Cost

The total cost of Retevmo can vary based on several factors, including your specific insurance plan, the dosage prescribed, and the pharmacy where the prescription is filled. As a specialty medication, Retevmo is typically dispensed through specialty pharmacies rather than standard retail locations.

Insurance Coverage

Insurance providers often require prior authorization before covering Retevmo. This means your healthcare provider must provide documentation to the insurance company to justify the medical necessity of the drug. Your out-of-pocket costs, such as copays or coinsurance, will depend on your plan's formulary and whether you have met your deductible.

Financial Assistance Programs

Financial support may be available to help reduce the cost of Retevmo:

Copay Cards: Eligible patients with commercial insurance may qualify for savings on their monthly out-of-pocket costs.

Patient Assistance Programs: Programs are often available for patients who are uninsured or underinsured and meet specific financial eligibility criteria.

Support Services: The manufacturer provides resources through the Lilly Oncology Support Center to help patients navigate insurance and find financial aid options.

Retevmo

Medication Quick Facts

📋Overview

What It's Used For

How It Works

Side Effects

Warnings & Precautions

Dosage & How to Take

Pregnancy & Breastfeeding

Forms & Strengths

FDA / Regulatory Status

Price Information

FAQ

Additional Resources

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