Cold Agglutinin Disease
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📋Overview
Cold Agglutinin Disease (CAD) is a rare form of autoimmune hemolytic anemia characterized by the presence of cold agglutinins—autoantibodies that bind to red blood cells at low temperatures, causing their clumping and destruction. It is considered a subtype of autoimmune hemolytic anemia and is distinct from cold agglutinin syndrome, which is secondary to infections or malignancies. CAD is the preferred modern term for this chronic condition.
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Medical codes (for reference)
UMLS CUI: C0175816ICD-10-CM
D59.12
MeSH
D000744
SNOMED CT (US)
398937006
Codes are provided for reference and interoperability. They are not a diagnosis.
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